Apoptosis Reagents and Kits
AdipoGen m-3M3FBS
Chemical. CAS 200933-14-8. Formula C16H16F3NO2S. MW 343.4. m-3M3FBS is a cell permeable and specific activator of phospholipase C PLC that has been shown to stimulate the PLC-mediated intracellular Ca2 release, inositol phosphates production and superoxide generation in various cell types. It activates all PLC isotypes beta2, beta3, gamma1, gamma2 and delta1 in vitro, but not heterotrimeric G proteins, PI 3-kinase or PLD. m-3M3FBS also affects calcium homeostasis independently of PLC activation. m-3M3FBS induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling. m-3M3FBS has been shown in vitro to trigger mitochondrial damage and activate NLRP10 a bona fide inflammasome binding to Asc and Caspase-1 in keratinocytes. NLRP10 acts also as inflammasome in intestine epithelial cells and protects against autoinflammation in the gut.
Abcam Human CD16 Antibody Pair - BSA and Azide free, 10 x 96 Tests
Human CD16 Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human CD16.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human Profilin 1 Antibody Pair - BSA and Azide free, 10 x 96 Tests
Human Profilin 1 Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human Profilin 1.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human MLKL Antibody Pair - BSA and Azide free, 10 x 96 Tests
Human MLKL Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human MLKL.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human/Monkey Cystatin C Antibody Pair - BSA and Azide free, 10 x 96 Tests
Human/Monkey Cystatin C Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human/Monkey Cystatin C.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human Estrogen Receptor alpha Antibody Pair - BSA and Azide free, 10 x 96 Tests
Human Estrogen Receptor alpha Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human Estrogen Receptor alpha.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human LTBR Antibody Pair - BSA and Azide free, 10 x 96 Tests
Human LTBR Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human LTBR.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology Caspase-1 Rabbit pAb
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Biotium NucView 488 and RedDot™ 2 Apoptosis & Necrosis Kit (100 assays)
NucView488 and RedDot™ Apoptosis/Necrosis Assay Kit contains NucView488 Caspase-3 Substrate for detection of caspase-3/7 activity. The far-red dead-cell stain RedDot™ is included for staining necrotic and late apoptotic cells that have compromised plasma membrane integrity. This kit provides a convenient tool for profiling apoptotic and necrotic cell populations by fluorescence microscopy or flow cytometry. In contrast to other fluorogenic caspase substrates or fluorescent caspase inhibitor based (FLICA) assays, NucView488 Caspase-3 Substrate can be used to detect caspase-3/7 activity within individual intact cells without inhibiting apoptosis progression. RedDot™ is a cell membrane-impermeable, far-red dye with high selectivity for membrane compromised or dead cells. RedDot™ has far-red emission at 695 nm for detection in the Cy5 channel, well-separated from the green fluorescence of NucView488. The kit has reagents sufficient for 100 assays for flow cytometry.
Cell Signaling Technology Cleaved Caspase-3 (Asp175) (D3E9) Rabbit mAb (Alexa Fluor 488 Conjugate) 100 µl
Cleaved Caspase-3 (Asp175) (D3E9) Rabbit mAb (Alexa Fluor 488 Conjugate) 100 µl
